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Prenatal Effects

 

 Pure Speculation on my part.   But I like this explanation better than most I've seen.

  

Autism

There is surely a number of things going on . The spectrum of symptoms clearly indicate a combination of factors.

 

I believe the first of these is IgG gluten intolerance in the mother. The antigliadin antibodies cross the placenta and bind to synapsin in the fetal brain causing developmental dysfunction in the nervous system and brain.
The second is gluten or casein intolerance in the child causing dysregulation of enteric nerves and glucose metabolism.

 

The research between gluten intolerance and autism in children currently focuses on gluten sensitivity in the patient.   I accept this link on the strength of their improvements on a restricted diet.

Study Implicates Hyperinsulinemia in Increased Incidence of Autism

 But since fetuses don't produce antibodies-  I am pretty sure the developmental damage is caused by maternal gluten intolerance.  

 

Low Birthweight Infants Five Times More Likely to Have Autism, Study Finds
Gluten intolerance is associated with smaller babies.

 

 

I suspect that gluten intolerance in the mother causes neurological variation in the fetal brain, which then is further exacerbated by autoimmunities and pathogens in the child.  This creates  a possible second order interaction-  depending whether only the mother is gluten sensitive, or the child is too.   And whether or not they have the same alleles.  Various outcomes can be imagined from the combination of antibodies produced by the mother, the offspring, any other infectious agents, and the time of exposure. 

  

  

Synapsin is critical in fetal brain development. It seems to act as a marker for where synapses should form.   It appears early and if not, brain cells do not connect to eachother properly. 

  

 Maternal antibodies may alter prenatal synapsin function.

  • IgG antibodies cross the placenta and are transferred in breast milk.   

  • And antibodies binding to neurons has been shown to occur.

Maternal immune response to fetal brain during pregnancy a key factor in some Autism

Maternally Derived Antibodies Specific for Fetal Brain Proteins

This experiment finds the binding protein mass is 73 kDa.

 

The antigliadin study results report protein binding at  "two closely spaced bands with molecular masses of 7378 kDa ".

 

Update:  I love Armin Alaedini!!

IgG gluten antibodies found in children with autism but no link to celiac disease

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I also believe that other disorders may contribute to the onset and presentation of autism.
Possibly in utero HSV3 infection. Or even post partum infection could contribute to the developmental problems.
And streptococcal autoimmunity may amplify the behavioral effects.

 

I haven't done any research to link it to viruses yet.   But autistic children have low levels of glutathione- possibly an indicator of herpes virus infection.

If it is a virus/antibody mediated process, then it seems possible that vaccination could affect the presentation of autism. It may introduce the very vector you're trying to avoid.   


If that is the case then vaccination may have a complicated effect...
MMR vaccine contains mercury. Most people assume the mercury causes the brain damage. Actually, mercury amplifies Herpes virus activation. And the varicella vaccine is given after the MMR. If the varicella vaccine is given to closely to the MMR vaccine, there is a much higher chance of breakthrough infection. I think that may be the actual problem.
I also wonder about, but do not know what the effect of the varicella vaccine would be for a child who has been pre or peri- natally infected.

 
 

 

  

 

 

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